Serum paraoxonase enzyme activity and oxidative stress in obese subjects

Serum paraoxonase enzyme activity and oxidative stress in obese subjects.

INTRODUCTION Obesity is an important risk factor for atherosclerotic cardiovascular disease. Paraoxonase-1 (PON1) may play a significant role in the prevention of obesity-related accelerated atherosclerosis by hydrolyzing lipid peroxides in oxidized low-density lipoproteins. OBJECTIVES The aim of this study was to evaluate PON1 and arylesterase enzyme activities and lipid hydroperoxide (LOOH)...

relationship between proteolytic enzyme activity and oxidative stress in subjects with diabetes

Serum Paraoxonase/Arylesterase Activity and Oxidative Stress Status in Children with Metabolic Syndrome

OBJECTIVE This study aimed to measure paraoxonase/arylesterase activities and to evaluate the total oxidant and antioxidant capacities in obese children and in children with metabolic syndrome (MetS). METHODS A total of 151 children of comparable ages (13.23±1.96 years, 13.45±1.85 years and 13.95±1.31 years) were enrolled in the study. Forty of these were children with MetS, 55 were obese and...

Serum Paraoxonase 1 Activity and Oxidative Stress in Pediatric Patients with Pulmonary Tuberculosis

OBJECTIVES The aim of this study was to determine the oxidative stress and paraoxonase 1 (PON1) levels in children with pulmonary tuberculosis (TB) compared to healthy controls, and to examine the association of demographical with oxidative stress. SUBJECTS AND METHODS Forty children diagnosed with pulmonary TB and 40 age- and gender-matched healthy controls were enrolled in the study. Serum ...

Determinants of variation in serum paraoxonase enzyme activity in baboons.

Paraoxonase (PON), an HDL-associated enzyme, is one of many circulating antioxidants thought to play a vital protective role. To better understand the determinants of quantitative variation in serum PON activity, we assayed PON in samples from 611 pedigreed baboons fed three diets. PON was measured enzymatically; the main determinant of variation was genetic and consisted of at least three comp...